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产品目录

Aurora A/AURKA抗体图片
产品货号:
Z33959
中文名称:
Aurora A/AURKA抗体
英文名称:
Anti-Aurora A/AURKA Antibody (Clone#1F8)
产品规格:
100μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-Aurora A/AURKA Antibody (Clone#1F8)
指标别名AIK;ARK 1;ARK1;AURA;AURKA;Aurora A;aurora kinase A;Aurora related kinase 1;Aurora/IPL1 related kinase 1;AURORA2;Breast tumor amplified kinase;BTAK;hARK1;STK15;STK6;STK7
克隆性Monoclonal
检验物种human,rat,monkey
应用范围WB,IF,FCM,ELISA
基因名称AURKA
克隆号1F8
抗体来源Mouse
抗体类型IgG
免疫原Purified recombinant fragment of human ARK-1 expressed in E.Coli.
计算分子量46KD
成分Ascitic fluid containing 0.03% sodium azide.
纯化方式Affinity purification
浓度1mg/mL
产品形态溶液
保存条件-20℃可保存1年,短期保存或频繁使用请置于4℃,可保存一个月,避免反复冻融。
背景资料AURKA(aurora kinase A),also called ARK1,AurA,AIK,AURORA2,BTAK,PPP1R47,STK7,STK15,STK6,is a mitotic centrosomal protein kinase.The main role of AURKA in tumor development is in controlling chromosome segregation during mitosis.Aurora A is a member of a family of mitotic serine/threonine kinases.Cell cycle and Northern blot analyses showed that peak expression of AURKA occurs during the G2/M phase and then decreases.By fluorescence in situ hybridization,AURKA gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42.The AURKA gene is overexpressed in many human cancers.Ectopic overexpression of Aurora kinase A in mammalian cells induces centrosome amplification,chromosome instability,and oncogenic transformation,a phenotype characteristic of loss-of-function mutations of p53.Depletion of Ajuba prevented activation of AURKA at centrosomes in late G2 phase and inhibited mitotic entry.Activation of AURKA was independently sufficient to induce rapid ciliary resorption,and AURKA acted in this process through phosphorylation of HDAC6,leading to HDAC6-dependent tubulin deacetylation and destabilization of the ciliary axoneme.Small molecule inhibitors of AURKA and HDAC6 reduced regulated disassembly of cilia.
Uniprot IDO14965
基因名全称Aurora kinase A
蛋白名全称Aurora kinase A
推荐稀释比WB 1:500~1:2000
IF 1:200~1:1000
FC 1:200~1:400
ELISA 1:10000

相关搜索:Aurora A/AURKA抗体Aurora A抗体AURKA单抗Anti-Aurora A/AURKA Antibody (Clone#1F8)
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